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Ofloxacin: Side Effects, Contraindications and Dosage

Review literature: (Simon und Stille, 1997).

Mechanism of Action of Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic, which interferes with the bacterial DNA synthesis via inhibition of the DNA gyrase or topoisomerase II. Fluoroquinolone antibiotics are bactericidal.

Indications for Ofloxacin

Ofloxacin is active against a variety of bacteria:

Gram-negative pathogens including Pseudomonas, Mycoplasma, Chlamydia,..
Gram-positive pathogens, but not Pneumococci or Enterococci
Some anaerobic bacteria

Urologic indications for ofloxacin are urinary tract infections, prostatitis, acute pyelonephritis, or epididymitis.

Pharmacokinetics of Ofloxacin

Good bioavailability after oral administration, maximum concentration in serum within 60 min after oral administration.
Good tissue penetration
Half-life of 6–7 h, renal elimination to 80–90%.

Side Effects of Ofloxacin

Gastrointestinal side effects: Nausea, vomiting, diarrhea, pseudomembranous colitis
Neurotoxicity with headache, dizziness, psychosis and seizures.
Allergy. Rarely serious allergic skin reactions.
Photosensitization
Orthopedic side effects: cartilage damage, tendon damage with spontaneous tendon rupture.
Rarely alterations of the blood count

Interactions with Ofloxacin:

Do not give iron salts or magnesium or aluminum-containing antacids together with ofloxacin. Ofloxacin increases increases warfarin and glibenclamid effect.

Contraindications to Ofloxacin

Pregnancy, lactation and children
Epilepsy
Patients with tendon damage after fluoroquinolone administration

Dosage of Ofloxacin

Normal dosage of ofloxacin is 200 mg 1-0-1 p.o. Reduced dosage in impaired renal or hepatic function to 100 mg 1-0-1 or 1-0-0. Treatment of uncomplicated gonorrhea with a single dose 400 mg p.o.

Levofloxacin

Index

Norfloxacin

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

References

Auquer u.a. 2002 AUQUER, F. ; CORDON, F. ; GORINA, E. ; CABALLERO, J. C. ; ADALID, C. ; BATLLE, J.: Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women.
In: Clin Microbiol Infect
8 (2002), Nr. 1, S. 50–4

Henry u.a. 2002 HENRY, Jr. ; BETTIS, R. B. ; RIFFER, E. ; HAVERSTOCK, D. C. ; KOWALSKY, S. F. ; MANNING, K. ; HAMED, K. A. ; CHURCH, D. A.: Comparison of once-daily extended-release ciprofloxacin and conventional twice-daily ciprofloxacin for the treatment of uncomplicated urinary tract infection in women.
In: Clin Ther
24 (2002), Nr. 12, S. 2088–104

Krcmery und Naber 1999 KRCMERY, S. ; NABER, K. G.: Ciprofloxacin once versus twice daily in the treatment of complicated urinary tract infections. German Ciprofloxacin UTI Study Group.
In: Int J Antimicrob Agents
11 (1999), Nr. 2, S. 133–8

Martin u.a. 1998 MARTIN, S. J. ; MEYER, J. M. ; CHUCK, S. K. ; JUNG, R. ; MESSICK, C. R. ; PENDLAND, S. L.: Levofloxacin and sparfloxacin: new quinolone antibiotics.
In: Ann Pharmacother
32 (1998), Nr. 3, S. 320–36

Mombelli u.a. 1999 MOMBELLI, G. ; PEZZOLI, R. ; PINOJA-LUTZ, G. ; MONOTTI, R. ; MARONE, C. ; FRANCIOLLI, M.: Oral vs. intravenous ciprofloxacin in the initial empirical management of severe pyelonephritis or complicated urinary tract infections: a prospective randomized clinical trial.
In: Arch Intern Med
159 (1999), Nr. 1, S. 53–8

Naber u.a. 1999 NABER, K. G. ; THEURETZBACHER, U. ; MONEVA-KOUCHEVA, G. ; STASS, H.: Urinary excretion and bactericidal activity of intravenous ciprofloxacin compared with oral ciprofloxacin.
In: Eur J Clin Microbiol Infect Dis
18 (1999), Nr. 11, S. 783–9

Raz u.a. 2000 RAZ, R. ; NABER, K. G. ; RAIZENBERG, C. ; ROHANA, Y. ; UNAMBA-OPARAH, I. ; KORFMAN, G. ; YANIV, I.: Ciprofloxacin 250 mg twice daily versus ofloxacin 200 mg twice daily in the treatment of complicated urinary tract infections in women.
In: Eur J Clin Microbiol Infect Dis
19 (2000), Nr. 5, S. 327–31

Reid u.a. 2000 REID, G. ; POTTER, P. ; DELANEY, G. ; HSIEH, J. ; NICOSIA, S. ; HAYES, K.: Ofloxacin for the treatment of urinary tract infections and biofilms in spinal cord injury.
In: Int J Antimicrob Agents
13 (2000), Nr. 4, S. 305–7

Simon und Stille 1997 SIMON, C. ; STILLE, W.: Antibiotika-Therapie in Klinik und Praxis.
9. Auflage.
Stuttgart New York : Schattauer, 1997

Talan u.a. 2004 TALAN, D. A. ; KLIMBERG, I. W. ; NICOLLE, L. E. ; SONG, J. ; KOWALSKY, S. F. ; CHURCH, D. A.: Once daily, extended release ciprofloxacin for complicated urinary tract infections and acute uncomplicated pyelonephritis.
In: J Urol
171 (2004), Nr. 2 Pt 1, S. 734–9

Deutsche Version: Nebenwirkungen, Kontraindikationen und Dosierung von Ofloxacin